BDBM629606 4-((4R)-2,2-difluoro-4-methyl-67-oxo-67,68-dihydro- 5- aza-6(4,8)-pyrido[2,3-d]pyrimidina-1(4,1)-piperidina- 3(1,3)-benzenacyclotridecaphane-66-yl)tetrahydro-2H- thiopyran-4-carbonitrile 1,1-dioxide::US20230339952, Compound 116

SMILES C[C@H]1Nc2ncnc3n(CCCCCCCN4CCC(CC4)C(F)(F)c4cccc1c4)c(=O)c(cc23)C1(CCS(=O)(=O)CC1)C#N

InChI Key InChIKey=VKFMNJGUFJVZFU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629606   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM629606(4-((4R)-2,2-difluoro-4-methyl-67-oxo-67,68-dihydro...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent