BDBM629610 (R)-1-(2,2-difluoro-4-methyl-7-oxa-5-aza-6(4,7)- pyrido[2,3-d]pyrimidina-1(4,1)-piperidina-3(1,3)- benzenacyclotridecaphane-66-yl)cyclopropane-1- carbonitrile::US20230339952, Compound 121

SMILES C[C@H]1Nc2ncnc3nc(OCCCCCCN4CCC(CC4)C(F)(F)c4cccc1c4)c(cc23)C1(CC1)C#N

InChI Key InChIKey=KKVXWFCHHYLOPJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629610   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM629610((R)-1-(2,2-difluoro-4-methyl-7-oxa-5-aza-6(4,7)- p...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent