BDBM629632 (4R,E)-2,2-difluoro-66-(1-isopropylpiperidin-4-yl)-4- methyl-67,68-dihydro-5-aza-6(4,8)-pyrido[2,3- d]pyrimidina-1(4,1)-piperidina-3(1,3)- benzenacyclotridecaphan-11-en-67-one::US20230339952, Compound 149

SMILES CC(C)N1CCC(CC1)c1cc2c3N[C@H](C)c4cccc(c4)C(F)(F)C4CCN(CC4)C\C=C\CCCCn(c2ncn3)c1=O

InChI Key InChIKey=LPTSMDFWTZNBHF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629632   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM629632((4R,E)-2,2-difluoro-66-(1-isopropylpiperidin-4-yl)...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent