BDBM629636 (3R)-5,5-difluoro-16-(4-isopropylpiperazin-1-yl)-3- methyl-17,18-dihydro-2-aza-1(4,8)-pyrido[2,3- d]pyrimidina-8(4,1)-piperidina-4(1,3)- benzenacyclotridecaphan-17-one::US20230339952, Compound 154

SMILES CC(C)N1CCN(c2cc3c4ncnc3n(c2=O)CCCCCN2CCC(CC2)CCC(F)(F)c2cccc(c2)[C@@H](C)N4)CC1

InChI Key InChIKey=JYGYYPOGWDGGTD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629636   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 629636BDBM629636((3R)-5,5-difluoro-16-(4-isopropylpiperazin-1-yl)-3...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent