BDBM629640 1-((4R)-32,2,2-trifluoro-4-methyl-67,8-dioxo-67,68- dihydro-5,9-diaza-6(4,8)-pyrido[2,3-d]pyrimidina- 1(4,1)-piperidina-3(1,3)-benzenacyclotridecaphane-66- yl)cyclopropane-1-carbonitrile::US20230339952, Compound 158

SMILES C[C@H]1Nc2ncnc3n(CC(=O)NCCCCN4CCC(CC4)C(F)(F)c4cccc1c4F)c(=O)c(cc23)C1(CC1)C#N

InChI Key InChIKey=LIBOLZUVFOTJHV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629640   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM629640(1-((4R)-32,2,2-trifluoro-4-methyl-67,8-dioxo-67,68...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent