BDBM629643 (3R)-16-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)- 5,5-difluoro-3-methyl-17,18-dihydro-2-aza-1(4,8)- pyrido[2,3-d]pyrimidina-7(3,1)-azetidina-4(1,3)- benzenacyclotetradecaphan-17-one::US20230339952, Compound 161

SMILES C[C@H]1Nc2ncnc3c2cc(C2CCS(=O)(=O)CC2)c(=O)n3CCCCCCCN2CC(C2)CC(F)(F)c2cccc1c2

InChI Key InChIKey=GWMRUFBCOMKFGN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629643   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 629643BDBM629643((3R)-16-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent