BDBM631055 (S)—N—((R)-(3-chloro-4-(trifluoromethoxy)phenyl)(1-(trifluoromethyl)-1H-pyrazol-4-yl)-l3-methyl)-2-oxoimidazolidine-4-carboxamide and (S)—N—((S)-(3-chloro-4-(trifluoromethoxy)phenyl)(1-(trifluoromethyl)-1H-pyrazol-4-yl)-l3-methyl)-2-oxoimidazolidine-4-carboxamide::US11802122, Example 41A::US11802122, Example 41B

SMILES FC(F)(F)Oc1ccc(cc1Cl)C(NC(=O)[C@@H]1CNC(=O)N1)c1cnn(c1)C(F)(F)F

InChI Key InChIKey=WIQHMOWOGITMKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 631055   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM631055(US11802122, Example 41A | US11802122, Example 41B ...)
Affinity DataIC50: 1.70nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM631055(US11802122, Example 41A | US11802122, Example 41B ...)
Affinity DataIC50: 16nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent