BDBM631159 US11802133, Example 11::US11802133, Example 8
SMILES c1cc(ccc1CC2CCN(CC2)C(=O)N3CC[C@H]4[C@@H](C3)NC(=O)CO4)C(F)(F)F
InChI Key InChIKey=YUPLWIRVNVZRHU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 631159
Affinity DataIC50: 13nMAssay Description:The 4-NPA assay was carried out in 384 well assay plates (black with clear bottom, non-binding surface treated, Corning Ref. 3655) in a total volume ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 32nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:The 4-NPA assay was carried out in 384 well assay plates (black with clear bottom, non-binding surface treated, Corning Ref. 3655) in a total volume ...More data for this Ligand-Target Pair
Affinity DataKd: 45nMAssay Description:Binding affinity to human MAGL assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 64nMAssay Description:Binding affinity to rat MAGL assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of rat MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by m...More data for this Ligand-Target Pair
Affinity DataIC50: 91nMAssay Description:Inhibition of mouse MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair