BDBM631620 US20230348424, Example 203

SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1CCN(C)C[C@@H]1F)C12CC(C1)C2)c1cccc(C(F)F)c1F

InChI Key InChIKey=YSTOKVADZPWGFF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 631620   

LigandPNGBDBM631620(US20230348424, Example 203)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent