BDBM631649 US20230348424, Example 232::US20230348424, Example 233

SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F

InChI Key InChIKey=DDTLOZRZRNWPBI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 631649   

LigandPNGBDBM631649(US20230348424, Example 232 | US20230348424, Exampl...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent

LigandPNGBDBM631649(US20230348424, Example 232 | US20230348424, Exampl...)
Affinity DataIC50: 91.9nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent