BDBM631681 US20230348424, Example 264

SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(C)CCN(C1)C(C)=O)c1cccc(C(F)F)c1F

InChI Key InChIKey=HXQHEMIJHJLRJP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 631681   

LigandPNGBDBM631681(US20230348424, Example 264)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent