BDBM631724 N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)-1-((R)-2,2- dimethyltetrahydro-2H-pyran-4-yl)-4-((1-methylpiperidin-4-yl)amino)-6-oxo-1,6- dihydropyridine-3-carboxamide (Example 307)::US20230348424, Example 307

SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC(C)(C)C2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F

InChI Key InChIKey=DAERMYNOIYKKFY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 631724   

LigandPNGBDBM631724(US20230348424, Example 307 | N-((R)-1-(3-(difluoro...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent