BDBM632977 N-(2-chloro-4- (difluoromethyl)thiophen-3-yl)-2-((2- methyl-6-(3,4-dimethylpiperazin-1- yl)pyrimidin-4-yl)amino)thiazole-5- carboxamide::US20230348453, Compound E16

SMILES CC1CN(CCN1C)c1cc(Nc2ncc(s2)C(=O)Nc2c(Cl)scc2C(F)F)nc(C)n1

InChI Key InChIKey=ODYLETLDBBYSCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 632977   

TargetSerine/threonine-protein kinase SIK2(Human)
Iomx Therapeutics

US Patent
LigandPNGBDBM632977(US20230348453, Compound E16 | N-(2-chloro-4- (difl...)
Affinity DataIC50: 20nMAssay Description:The IC50 for the inhibition of ABL1 by dasatinib, by C7 and by B3 is approximately 1.5 nM, 5.1 nM and 1.6 nM, and of SRC is 1.5 nM, 1.5 nM and 1.5 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Iomx Therapeutics

US Patent
LigandPNGBDBM632977(US20230348453, Compound E16 | N-(2-chloro-4- (difl...)
Affinity DataIC50: 35nMAssay Description:The IC50 for the inhibition of ABL1 by dasatinib, by C7 and by B3 is approximately 1.5 nM, 5.1 nM and 1.6 nM, and of SRC is 1.5 nM, 1.5 nM and 1.5 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent