BDBM633237 US20230348495, Example 31

SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CC2CCC(C1)N2)c1cc(O)cc2cccc(Br)c12

InChI Key InChIKey=ZZYUDMDZBIXIJW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 633237   

TargetGTPase KRas [G12D](Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM633237(US20230348495, Example 31)
Affinity DataIC50: 17.7nMAssay Description:For the measurement of the inhibitory activity of compounds on GDP-GTP exchange rate of recombinant KRAS G12D, BODIPY FL GDP-bound KRAS G12D protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent