BDBM633434 N-(4-(7-methoxy-3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)benzyl)sulfamide hydrochloride::US20230159469, Example 105

SMILES COc1ccc2c(c1)c(nn(C)c2=O)-c1ccc(CNS(N)(=O)=O)cc1

InChI Key InChIKey=VCOIRNWCZBKDGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633434   

LigandPNGBDBM633434(N-(4-(7-methoxy-3-methyl-4-oxo-3,4-dihydrophthalaz...)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633434(N-(4-(7-methoxy-3-methyl-4-oxo-3,4-dihydrophthalaz...)
Affinity DataIC50: 5.50E+3nMAssay Description:ENPP1 hydrolyzes nucleotides or nucleotide derivatives to produce nucleoside -5′-monophosphate and pyrophosphate. in addition, ENPP1 hydrolyzes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent