BDBM633458 6-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride::US20230159469, Example 129

SMILES Cn1nc(-c2ccc3CN(CCc3c2)S(N)(=O)=O)c2ccccc2c1=O

InChI Key InChIKey=RWLPGRWCSCZLRB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633458   

LigandPNGBDBM633458(6-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-3,4-...)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633458(6-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-3,4-...)
Affinity DataIC50: 5.50E+3nMAssay Description:ENPP1 hydrolyzes nucleotides or nucleotide derivatives to produce nucleoside -5′-monophosphate and pyrophosphate. in addition, ENPP1 hydrolyzes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent