BDBM633477 5-((6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1-yl)methyl)indoline-1-sulfonamide hydrochloride::US20230159469, Example 187

SMILES COc1cc2c(Cc3ccc4N(CCc4c3)S(N)(=O)=O)n[nH]c(=O)c2cc1OC

InChI Key InChIKey=ZIUSKTOETOYWFY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633477   

LigandPNGBDBM633477(5-((6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1-yl...)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633477(5-((6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:ENPP1 hydrolyzes nucleotides or nucleotide derivatives to produce nucleoside -5′-monophosphate and pyrophosphate. in addition, ENPP1 hydrolyzes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
US Patent