BDBM633930 US11807649, Compound 5

SMILES Cc1cc(Nc2ncnc3cc4OC[C@H]5CN(CCN5C(=O)C=C)c4cc23)ccc1Oc1ccn2ncnc2c1

InChI Key InChIKey=HIHLUKUSGNSQKB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 633930   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633930(US11807649, Compound 5)
Affinity DataIC50: 7.36nMAssay Description:Table B3: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phospho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633930(US11807649, Compound 5)
Affinity DataIC50: 1.20E+3nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phosphorylated an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633930(US11807649, Compound 5)
Affinity DataIC50: 1.86E+3nMAssay Description:Table B4: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated EGFR levels using A431 cells (10% FBS). A431 (1.0*104ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633930(US11807649, Compound 5)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated EGFR levels using A431 cells (10% FBS). A431 (1.0*104 cells/40 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2023
Entry Details
US Patent