BDBM633949 US11807649, Compound 24

SMILES Cc1cc(Nc2ncnc3cc4c(nc23)N2CCN(C(=O)/C=C/CN(C)C)[C@H](CO4)C2)c(F)cc1Oc1ccn2ncnc2c1

InChI Key InChIKey=SDAXRPZVCMFHRU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633949   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Enliven Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 633949BDBM633949(US11807649, Compound 24)
Affinity DataIC50: 8.38nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phosphorylated an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Enliven Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 633949BDBM633949(US11807649, Compound 24)
Affinity DataIC50: 2.16E+3nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated EGFR levels using A431 cells (10% FBS). A431 (1.0*104 cells/40 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2023
Entry Details
US Patent