BDBM633966 Synthesis of (E)-1-((10S)-4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-2-fluoro-5-methylphenyl)amino)-7,8,10,11-tetrahydro-9H-6,10-methanopyrimido[4′,5′:5,6]pyrido[3,2-b][1,4,7]oxadiazonin-9-yl)-34-((R)-1-methylpyrrolidin-2-yl)prop-2-en-1-one ::US11807649, Compound 41

SMILES CN1CCC[C@@H]1\C=C\C(=O)N1CCN2C[C@H]1COc1cc3ncnc(Nc4cc(C)c(Oc5ccn6ncnc6c5)cc4F)c3nc21

InChI Key InChIKey=BGSATZMDRDKLQL-YPXJWJENSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633966   

TargetEpidermal growth factor receptor(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633966(Synthesis of (E)-1-((10S)-4-((4-([1,2,4]triazolo[1...)
Affinity DataIC50:  7.30E+3nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated EGFR levels using A431 cells (10% FBS). A431 (1.0*104 cells/40 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReceptor tyrosine-protein kinase erbB-2(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM633966(Synthesis of (E)-1-((10S)-4-((4-([1,2,4]triazolo[1...)
Affinity DataIC50:  24.5nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phosphorylated an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent