BDBM634113 BDBM634121::US20230357248, Example 4

SMILES CO[C@@H]1C[C@@H](CO)OC[C@@H]1Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12

InChI Key InChIKey=BRLPFUOPRDLXPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 634113   

TargetTyrosine-protein kinase BTK [C481S](Human)
Medshine Discovery

US Patent
LigandPNGBDBM634113(BDBM634121 | US20230357248, Example 4)
Affinity DataIC50: 7.30nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Medshine Discovery

US Patent
LigandPNGBDBM634113(BDBM634121 | US20230357248, Example 4)
Affinity DataIC50: 15.1nMAssay Description:The specific assay process of BTK enzyme activity assay is as follows: Buffer: 20 mM 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (Hepes) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
US Patent