BDBM634336 4-(3,3-difluoropyrrolidin-1-yl)-8,14-dioxa-::US20230357269, Example 21

SMILES O=C1NCCCOc2ccc3[nH]nc(c3c2)-c2cc(cc(N3CCC(F)(F)C3)c2)CO1

InChI Key InChIKey=HZTFQWJHVCYKPH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634336   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 634336BDBM634336(US20230357269, Example 21 | 4-(3,3-difluoropyrroli...)
Affinity DataIC50: 10nMAssay Description:LRRK2 Kinase reactions were carried out in 384-well white polystyrene plates in a final volume of 6 μl using ADP-Glo Kinase Assay kit (Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
US Patent