BDBM635425 N-(5-(8-(8-oxa-3-azabicyclo[3.2.1]octan-3- yl)imidazo[1,2-a]pyridin-6-yl)-2-fluoro-4- methylphenyl)-1-(tert-butyl)-5-fluoro-1H- pyrazole-4-carboxamide::US11814384, Example 180

SMILES Cc1cc(F)c(NC(=O)c2cnn(c2F)C(C)(C)C)cc1-c1cc(N2CC3CCC(C2)O3)c2nccn2c1

InChI Key InChIKey=ODMHVEQZYMSRIO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 635425   

TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM635425(N-(5-(8-(8-oxa-3-azabicyclo[3.2.1]octan-3- yl)imid...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent