BDBM635431 2-{Bicyclo[1.1.1]pentan-1-yl}-N-{2-fluoro-4- methyl-5-[8-(morpholin-4-yl)imidazo[1,2- a]pyridin-6-yl]phenyl}pyridine-4-carboxamide::US11814384, Example 188

SMILES Cc1cc(F)c(NC(=O)c2ccnc(c2)C23CC(C2)C3)cc1-c1cc(N2CCOCC2)c2nccn2c1

InChI Key InChIKey=AFPVGMKBBNTSPD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 635431   

TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM635431(2-{Bicyclo[1.1.1]pentan-1-yl}-N-{2-fluoro-4- methy...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM635431(2-{Bicyclo[1.1.1]pentan-1-yl}-N-{2-fluoro-4- methy...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent