BDBM635490 US11814388, Compound 5

SMILES O=C(Nc1ccc(Nc2ncnc3[nH]ccc23)cc1)c1ccccc1

InChI Key InChIKey=OHEAMFYXJIKCRE-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 635490   

TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  470nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  470nMAssay Description:Binding affinity to human partial length AURKB (D25 to A303 residues) expressed in mammalian system assessed as dissociation constant by DiscoverX ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  470nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetAurora kinase A(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  1.60E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetAurora kinase A(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  1.60E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  3.00E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  3.00E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system assessed as dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor [L858R](Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  3.00E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to wild type human EGFR partial length (R669 to V1011 residues) expressed in bacterial expression system assessed as dissociation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataKd:  3.00E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataIC50: 4.76E+4nMAssay Description:Inhibition of EGFR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM635490(US11814388, Compound 5 | US12410173, Compound 5)
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed