BDBM635492 US11814388, Compound 7
SMILES O=C(Nc1ccccc1)c1ccc(Nc2ncnc3[nH]ccc23)cc1
InChI Key InChIKey=WDVLOKNHMBINOL-UHFFFAOYSA-N
Data 4 Kd
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 635492
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Ferris State University
Curated by ChEMBL
Ferris State University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of AURKB/INCENP (unknown origin) preincubated for 60 mins in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Affinity DataKd: 440nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataKd: 440nMAssay Description:Binding affinity to wild type human EGFR partial length (R669 to V1011 residues) expressed in bacterial expression system assessed as dissociation co...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Ferris State University
Curated by ChEMBL
Ferris State University
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of AURKB/INCENP (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Affinity DataKd: 900nMAssay Description:Binding affinity to human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system assessed as dissociation...More data for this Ligand-Target Pair
Affinity DataKd: 900nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataKd: 1.50E+3nMAssay Description:Binding affinity to human partial length AURKB (D25 to A303 residues) expressed in mammalian system assessed as dissociation constant by DiscoverX ki...More data for this Ligand-Target Pair
Affinity DataKd: 1.50E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of AURKB (unknown origin) by nanoBRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.60E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataIC50: 2.06E+4nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation (unknown origin) preincubated for 60 mins in the presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of EGFR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair