BDBM636919 N-(4-(4-(6-(3,3-difluoroazetidin-1- yl)pyridin-2-yl)-1H-1,2,3-triazol-1-yl)-3- (6-azaspiro[2.5]octan-6- yl)phenyl)ethanesulfonamide::US20230382889, Compound 61

SMILES CCS(=O)(=O)Nc1ccc(c(c1)N1CCC2(CC2)CC1)-n1cc(nn1)-c1cccc(n1)N1CC(F)(F)C1

InChI Key InChIKey=RRVZKIYVXKGHDE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 636919   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636919(US20230382889, Compound 61 | N-(4-(4-(6-(3,3-diflu...)
Affinity DataIC50: 8nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent