BDBM636925 N-(4-(4-(2-(4,4-difluoropiperidin-1-yl)-6- methylpyrimidin-4-yl)-1H-1,2,3-triazol-1- yl)-3-(piperidin-1-yl)phenyl)-2- hydroxyethane-1-sulfonamide::US20230382889, Compound 67

SMILES Cc1cc(nc(n1)N1CCC(F)(F)CC1)-c1cn(nn1)-c1ccc(NS(=O)(=O)CCO)cc1N1CCCCC1

InChI Key InChIKey=GKHCVLCQOAZMHY-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636925   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636925(US20230382889, Compound 67 | N-(4-(4-(2-(4,4-diflu...)
Affinity DataKi:  1.70nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636925(US20230382889, Compound 67 | N-(4-(4-(2-(4,4-diflu...)
Affinity DataIC50: 22nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent