BDBM636926 N-(4-(4-(6-(4,4-difluoropiperidin-1-yl)-4- methylpyridin-2-yl)-1H-1,2,3-triazol-1- yl)-3-(piperidin-1-yl)phenyl)-2- hydroxyethane-1-sulfonamide::US20230382889, Compound 68

SMILES Cc1cc(nc(c1)-c1cn(nn1)-c1ccc(NS(=O)(=O)CCO)cc1N1CCCCC1)N1CCC(F)(F)CC1

InChI Key InChIKey=WZNCREDIYLIMRB-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636926   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636926(US20230382889, Compound 68 | N-(4-(4-(6-(4,4-diflu...)
Affinity DataKi:  0.820nMAssay Description:Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636926(US20230382889, Compound 68 | N-(4-(4-(6-(4,4-diflu...)
Affinity DataIC50: 12nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent