BDBM637496 (3-amino-5-chloro-6- cyclopropyl-1H-pyrazolo[3,4- b]pyridin-1-yl)(2- methoxyphenyl)methanone::US20230382911, Example 8

SMILES COc1ccccc1C(=O)n1nc(N)c2cc(Cl)c(nc12)C1CC1

InChI Key InChIKey=GYWBXSLVXWONLG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 637496   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637496(US20230382911, Example 8 | (3-amino-5-chloro-6- cy...)
Affinity DataIC50: 56nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent