BDBM637614 (R)-(3-aminopiperidin-1-yl)(2-(3-ethylbenzo[b]thiophen-2-yl)-3,4-dihydro-5-oxa-1,2a-diazaacenaphthylen-7-yl)methanone::US11833156, Example 12

SMILES CCc1c(sc2ccccc12)-c1nc2cc(cc3OCCn1c23)C(=O)N1CCC[C@@H](N)C1

InChI Key InChIKey=OTTXISGXVQCDKH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 637614   

TargetProtein-arginine deiminase type-4(Human)
Jubilant Epipad

US Patent
LigandPNGBDBM637614((R)-(3-aminopiperidin-1-yl)(2-(3-ethylbenzo[b]thio...)
Affinity DataIC50: 100nMAssay Description:Binding of compounds with PAD4 enzyme was detected by FP assay. PAD4 enzyme was diluted to 1 uM in assay buffer (100 mM HEPES, 50 mM NaCl, 1 mM DTT, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent

TargetProtein-arginine deiminase type-4(Human)
Jubilant Epipad

US Patent
LigandPNGBDBM637614((R)-(3-aminopiperidin-1-yl)(2-(3-ethylbenzo[b]thio...)
Affinity DataIC50: 1.00E+3nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent