BDBM637638 US20230382923, Compound 33

SMILES Cc1cc(Nc2ncnc3cc4OC[C@H]5CN(CCN5C(=O)C=C)c4nc23)ccc1Oc1ccn2ccnc2c1

InChI Key InChIKey=RFABPKSSVXQXLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 637638   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM637638(US20230382923, Compound 33)
Affinity DataIC50: 16.8nMAssay Description:Table B3: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phospho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM637638(US20230382923, Compound 33)
Affinity DataIC50: 164nMAssay Description:Table B4: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated EGFR levels using A431 cells (10% FBS). A431 (1.0*104ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent