BDBM637648 US20230382923, Compound 43

SMILES CN(C)C\C=C\C(=O)N1CCN2C[C@@H]1COc1cc3ncnc(Nc4cc(Cl)c(Oc5ccn6ncnc6c5)cc4F)c3nc21

InChI Key InChIKey=YJWLRYKQENHRPO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 637648   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM637648(US20230382923, Compound 43)
Affinity DataIC50: 8.69nMAssay Description:Table B3: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phospho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Enliven Therapeutics

US Patent
LigandPNGBDBM637648(US20230382923, Compound 43)
Affinity DataIC50: 1.40E+3nMAssay Description:Table B4: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated EGFR levels using A431 cells (10% FBS). A431 (1.0*104ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent