BDBM638391 Synthesis of (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl 4-(6-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)hexyl)piperazine-1-carboxylate ::US11834458, Example 2

SMILES CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCN(CCCCCCOc4cc(F)c(C5N(CC(C)(C)F)[C@H](C)Cc6c5[nH]c5ccccc65)c(F)c4)CC3)cc12

InChI Key InChIKey=LOQRDBIFDUONAY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 638391   

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638391(US11834458, Example 2 | Synthesis of (S)-4,11-diet...)
Affinity DataIC50: 10nMAssay Description:ERα binding was assessed using the LanthaScreen TR-FRET ER Alpha Competitive Binding kit from ThermoFisherScientific. In this assay, a terbium-l...More data for this Ligand-Target Pair
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Date in BDB:
1/23/2024
Entry Details
US Patent