BDBM638392 Synthesis of (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl 4-(6-((4-((8S,11R,13S,14S,17R)-17-acetoxy-17-acetyl-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)phenyl)(methyl)amino)hexanoyl)piperazine-1-carboxylate ::US11834458, Example 3

SMILES CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCN(CC3)C(=O)CCCCCN(C)c3ccc(cc3)[C@H]3C[C@@]4(C)[C@@H](CC[C@]4(OC(C)=O)C(C)=O)[C@@H]4CCC5=CC(=O)CCC5=C34)cc12

InChI Key InChIKey=ZUWLIHPMSJWXOJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 638392   

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638392(US11834458, Example 3 | Synthesis of (S)-4,11-diet...)
Affinity DataIC50: 10nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent

TargetGlucocorticoid receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638392(US11834458, Example 3 | Synthesis of (S)-4,11-diet...)
Affinity DataIC50: 10nMAssay Description:To assess GR binding, test compound (top dose 1 μM, 4 fold serial dilution, 8 point dose response) and control (dexamethasone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent