BDBM638400 Preparation of N-((1r,4r)-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-4-((6-(4-(((S)-4-ethyl-4,9-dihydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-10-yl)methyl)piperazin-1-yl)-6-oxohexyl)oxy)benzamide ::US11834458, Example 12

SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN5CCN(CC5)C(=O)CCCCCOc5ccc(cc5)C(=O)N[C@H]5CC[C@@H](CC5)Oc5ccc(C#N)c(Cl)c5)c4cc3Cn1c2=O

InChI Key InChIKey=VYYVFLNOSAVPRR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 638400   

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638400(US11834458, Example 12 | Preparation of N-((1r,4r)...)
Affinity DataIC50: 1.00E+3nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
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Date in BDB:
1/23/2024
Entry Details
US Patent