BDBM638401 Preparation of (S)-10-((Dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl 4-(6-(3,5-difluoro-4-((1S,3S)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)hexyl)piperazine-1-carboxylate ::US11834458, Example 13

SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(OC(=O)N5CCN(CCCCCCOc6cc(F)c([C@H]7N(CC(C)(C)F)[C@H](C)Cc8c7[nH]c7ccccc87)c(F)c6)CC5)c(CN(C)C)c4cc3Cn1c2=O

InChI Key InChIKey=KMJAYLYYCDBLFD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 638401   

TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638401(US11834458, Example 13 | Preparation of (S)-10-((D...)
Affinity DataIC50: 255nMAssay Description:ERα binding was assessed using the LanthaScreen TR-FRET ER Alpha Competitive Binding kit from ThermoFisherScientific. In this assay, a terbium-l...More data for this Ligand-Target Pair
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Date in BDB:
1/23/2024
Entry Details
US Patent