BDBM638404 Preparation of (S)-10-((Dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl (1-(2-(((5S,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)oxy)acetyl)piperidin-4-yl)(methyl)carbamate ::US11834458, Example 20

SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(OC(=O)N5CCC(CC5)N(C)C(=O)CO[C@H]5CC[C@H]6[C@@H]7CC[C@H]8CC(=O)CC[C@]8(C)[C@H]7CC[C@]56C)c(CN(C)C)c4cc3Cn1c2=O

InChI Key InChIKey=ODBNIGKQQOFYLH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 638404   

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638404(US11834458, Example 20 | Preparation of (S)-10-((D...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
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Date in BDB:
1/23/2024
Entry Details
US Patent