BDBM639209 4-((cis-3-(dimethylamino)cyclobutyl)ethynyl)-7-isopropoxy-1-(((S)-5-oxopyrrolidin-2-yl)methoxy)isoquinoline-6-carboxamide::US20230391748, Compound I-31

SMILES CC(C)Oc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#C[C@H]3C[C@H](C3)N(C)C)c2cc1C(N)=O

InChI Key InChIKey=IILMINRDAYNKAC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639209   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM639209(4-((cis-3-(dimethylamino)cyclobutyl)ethynyl)-7-iso...)
Affinity DataIC50: 3.5nMAssay Description:The ADP-Glo reagents were thawed at ambient temperature. The Kinase Detection Reagent was prepared by mixing kinase detection buffer with the lyophil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent