BDBM639227 (S)-1-((4,4-difluoro-5-oxopyrrolidin-2-yl)methoxy)-7-isopropoxy-4-((tetrahydro-2H-pyran-4-yl)ethynyl)isoquinoline-6-carboxamide::US20230391748, Compound I-49

SMILES CC(C)Oc1cc2c(OC[C@@H]3CC(F)(F)C(=O)N3)ncc(C#CC3CCOCC3)c2cc1C(N)=O

InChI Key InChIKey=DKQDCRLLWVPPAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639227   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM639227((S)-1-((4,4-difluoro-5-oxopyrrolidin-2-yl)methoxy)...)
Affinity DataIC50: 7.60nMAssay Description:The ADP-Glo reagents were thawed at ambient temperature. The Kinase Detection Reagent was prepared by mixing kinase detection buffer with the lyophil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent