BDBM639255 1-(((S)-4,4-difluoro-5-oxopyrrolidin-2-yl)methoxy)-4-(1-(trans-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)-7-isopropoxyisoquinoline-6-carboxamide::US20230391748, Compound I-77

SMILES CCO[C@H]1CC[C@@H](CC1)n1cc(cn1)-c1cnc(OC[C@@H]2CC(F)(F)C(=O)N2)c2cc(OC(C)C)c(cc12)C(N)=O

InChI Key InChIKey=PMTIXMBUGUJEDC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639255   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM639255(1-(((S)-4,4-difluoro-5-oxopyrrolidin-2-yl)methoxy)...)
Affinity DataIC50: 7nMAssay Description:The ADP-Glo reagents were thawed at ambient temperature. The Kinase Detection Reagent was prepared by mixing kinase detection buffer with the lyophil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent