BDBM639547 3,4-Dichloro-10-(1H-pyrazol-4-yl)-6,7,8,9-tetrahydropyrido[1,2-a]indole-8-carboxylic acid Isomer 1::US20230391786, Example 13

SMILES OC(=O)[C@H]1CCn2c(C1)c(-c1cn[nH]c1)c1ccc(Cl)c(Cl)c21

InChI Key InChIKey=AOIWJKBSGFUOCU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639547   

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639547(US20230391786, Example 13 | 3,4-Dichloro-10-(1H-py...)
Affinity DataIC50: 11.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
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Date in BDB:
1/28/2024
Entry Details
US Patent