BDBM639684 2-[4-[6-Chloro-5-methoxy-3-(1H-pyrazol-4-yl)indol-1-yl]triazol-1-yl]ethanol::US20230391786, Example 152

SMILES COc1cc2c(cn(-c3cn(CCO)nn3)c2cc1Cl)-c1cn[nH]c1

InChI Key InChIKey=MEWKJCFRNMIPDP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639684   

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639684(US20230391786, Example 152 | 2-[4-[6-Chloro-5-meth...)
Affinity DataIC50: 14.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent