BDBM639729 3-[[6,7-Dichloro-1-[1-(2-hydroxyethyl)triazol-4-yl]-3-(1H-pyrazol-4-yl)indol-4-yl]amino]propan-1-ol::US20230391786, Example 198

SMILES OCCCNc1cc(Cl)c(Cl)c2n(cc(-c3cn[nH]c3)c12)-c1cn(CCO)nn1

InChI Key InChIKey=WXDJRGCKKQJHDF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639729   

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639729(US20230391786, Example 198 | 3-[[6,7-Dichloro-1-[1...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent