BDBM639756 N-[6,7-Dichloro-2-(2-hydroxyethyl)-3-(1H-pyrazol-4-yl)-1H-indol-4-yl]-2,2-difluoro-acetamide::US20230391786, Example 225

SMILES OCCc1[nH]c2c(Cl)c(Cl)cc(NC(=O)C(F)F)c2c1-c1cn[nH]c1

InChI Key InChIKey=LWIBIVALWKSYIE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639756   

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639756(US20230391786, Example 225 | N-[6,7-Dichloro-2-(2-...)
Affinity DataIC50: 12.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
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Date in BDB:
1/28/2024
Entry Details
US Patent