BDBM639874 (S)—N-(5,6-Dichloro-8-ethoxy-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)-2-hydroxyacetamide::US20230391786, Example 343

SMILES CCOc1cc(Cl)c(Cl)c2n3CC[C@H](NC(=O)CO)c3c(-c3cn[nH]c3)c12

InChI Key InChIKey=VMICNWWNJMCRBS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639874   

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639874((S)—N-(5,6-Dichloro-8-ethoxy-9-(1H-pyrazol-4-...)
Affinity DataIC50: 6.14nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent