BDBM639884 5-[6-(2-Benzo[b]thiophen-5-yl-ethylamino)-pyrimidin-4-yl]-3-ethoxy-thiophene-2- carboxylic acid::US11839613, Example 5

SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3sccc3c2)ncn1

InChI Key InChIKey=AKAKKBQDQJBVJW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 639884   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM639884(5-[6-(2-Benzo[b]thiophen-5-yl-ethylamino)-pyrimidi...)
Affinity DataIC50: 3nMAssay Description:The BT549 cells (NCI/No. 0507282) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM639884(5-[6-(2-Benzo[b]thiophen-5-yl-ethylamino)-pyrimidi...)
Affinity DataIC50: 28nMAssay Description:The SF295 cells (NCI/No. 0503170) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2024
Entry Details
US Patent