BDBM639890 3-Ethoxy-5-{6-[2-(1-fluoro-naphthalen-2-yl)-ethylamino]-pyrimidin-4-yl}-thiophene-2- carboxylic acid::US11839613, Example 11

SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3ccccc3c2F)ncn1

InChI Key InChIKey=JWVHNSZQYTVMAZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 639890   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM639890(3-Ethoxy-5-{6-[2-(1-fluoro-naphthalen-2-yl)-ethyla...)
Affinity DataIC50: 7nMAssay Description:The BT549 cells (NCI/No. 0507282) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM639890(3-Ethoxy-5-{6-[2-(1-fluoro-naphthalen-2-yl)-ethyla...)
Affinity DataIC50: 277nMAssay Description:The SF295 cells (NCI/No. 0503170) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2024
Entry Details
US Patent