BDBM640378 Preparation of N-(3-((4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl)-4-methylphenyl)-4-methyl-3-(trifluoromethyl)benzamide ::US11840535, Example 20

SMILES Cc1ccc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)cc1C#Cc1cn(C2CCCC2)c2ncnc(N)c12

InChI Key InChIKey=WMYFOUZFYXBFOE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 640378   

TargetTyrosine-protein kinase ABL1(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM640378(Preparation of N-(3-((4-amino-7-cyclopentyl-7H-pyr...)
Affinity DataIC50: 27.5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [T315I](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM640378(Preparation of N-(3-((4-amino-7-cyclopentyl-7H-pyr...)
Affinity DataIC50: 75nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
US Patent