BDBM641289 US11845723, Example 183

SMILES CC#Cc1ccc2c(nc3nncn3c2c1)N(C)c1cccc(c1)-c1ccc(C)cc1

InChI Key InChIKey=SUAYCPOMBIQYEG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 641289   

TargetDiacylglycerol kinase alpha(Human)
Gilead Sciences

US Patent
LigandPNGBDBM641289(US11845723, Example 183)
Affinity DataIC50: 6nMAssay Description:Table 5: The IC50 value was calculated via a regression analysis of the inhibition rate (%) measured from the intensity of the luminescence at each c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2024
Entry Details
US Patent

TargetDiacylglycerol kinase alpha(Human)
Gilead Sciences

US Patent
LigandPNGBDBM641289(US11845723, Example 183)
Affinity DataIC50: 12.8nMAssay Description:Table 6: Alternatively, the enzymatic activity of human DGKα was monitored in a biochemical assay in the presence or absence of compounds and us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2024
Entry Details
US Patent